A study by Swedish researchers has found that boosting vitamin D levels in postmenopausal women to proper levels provides potent protection against urinary tract infections (UTIs). The researchers noted that vitamin D induces the production of cathelicidin, a human antimicrobial peptide secreted by bladder epithelial cells. Cathelicidin protects the urinary tract from threatening infections. The researchers examined biopsied bladder tissue from healthy postmenopausal women before and after intake of vitamin D over three months. Bladder cells infected with the bacterium E. coli, which causes UTI, showed a significant increase in cathelicidin expression after vitamin D supplementation. Taking a supplement to restore appropriate vitamin D levels “may therefore help prepare the bladder epithelium to mount a stronger and faster immune response once bacteria enter the bladder,” researchers concluded.
"Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder", PLoS ONE, December 14, 2011
A meta-analysis of prior non-clinical studies that focused on vitamin D levels and three types of cancer found that high levels of vitamin D in the blood were associated with a reduced risk of colorectal cancer, but not of breast or prostate cancer. The multinational team of researchers found that the risk of colorectal cancer declined by 15 percent for every 10 nanograms per milliliter increase in levels of vitamin D (25-hydroxyvitamin D). The researchers concluded that randomized clinical trials would be required to determine whether increasing vitamin D levels would change the risk of colorectal cancer and how much of an increase would be “useful as a public health measure.”
"Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma", International Journal of Cancer, March 15, 2011
Researchers in Australia have found that people with higher levels of vitamin D from any source and who have had greater exposure to the sun are less likely to develop multiple sclerosis. The study compared people who have shown the first symptoms – a “first event” – of MS, but haven’t yet been diagnosed, with people who have never shown symptoms. Researchers took into account time spent in the sun, skin damage from the sun and vitamin D levels from the sun, as well as from diet and supplements. The risk of having a first event of MS dropped with greater sun exposure, greater sun-damaged skin and higher levels of vitamin D.
"Sun exposure and vitamin D are independent risk factors for CNS demyelination", Neurology, February 07, 2011
A U.S. study that compared the antioxidant content of cocoa powder and cocoa products to various “Super Fruit”-derived powders and juices has found that cocoa powder and dark chocolate are not only a rich source of antioxidants, they contain more polyphenols and flavanols than fruit juices from blueberries, cranberries and pomegranates. The researchers, all of whom work for the Hershey Center for Health & Nutrition, found that gram per gram there was more antioxidant capacity and a greater total flavanol content in the cocoa powder than in fruit juices. Only hot chocolate mix lacked antioxidants, because of the alkalization process. The researchers said that cacao seeds even provide nutritive value beyond their macronutrient composition “and appear to meet the popular media’s definition of a ‘Super Fruit’.”
"Cacao seeds are a "Super Fruit": A comparative analysis of various fruit powders and products", Chemistry Central Journal, February 07, 2011
A British/Canadian study of 4,000 children born in 1991-92 has found that a diet of mainly processed food high in fats and sugars at age three was associated with a lower IQ at the age of 8.5, whether or not the diet improved after that age. Likewise, a healthy diet rich in vitamins and nutrients at age three was associated with a higher IQ at the age of 8.5. Every one point increase in dietary pattern was linked to a 1.2 increase in IQ. Dietary patterns between the ages of 4 and 7 had no impact on IQ. Researchers identified three dietary patterns: "processed;" "traditional" (meat and vegetables); and "health conscious" (salad, fruit, vegetables, rice and pasta). Scores were calculated for each pattern for each child.
"Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study", Journal of Epidemiology & Community Health, February 07, 2011
People who need to reduce consumption of high-calorie (energy-dense) foods can do so by adding more vegetables to their diet – if they can stand the taste. Tackling that problem, U.S. researchers have found that puréed vegetables added secretly to meals makes it easier to eat less energy-dense meals. The study involved 41 men and women who ate breakfast, lunch and dinner in the laboratory once a week for three weeks. Entrées contained either standard energy density or reduced energy density from the “covert incorporation of three to 4.5 times the amount of puréed vegetables.” The researchers found that the decreased energy intake of the vegetable-rich meals did not affect feelings of fullness or hunger and provided a good way to boost vegetable consumption.
"Hidden vegetables: an effective strategy to reduce energy intake and increase vegetable intake in adults", The American Journal of Clinical Nutrition, February 02, 2011
Canadian food scientists have found that the predominant antioxidants in dark roasted coffee are derived from the browning of green beans at high temperatures, not from caffeine or other sources. The scientists analyzed the complex combination of chemical compounds produced during coffee bean roasting, a process known as the “Maillard reaction” after the scientist who first studied heat’s effect on carbohydrates, sugars and proteins in food. Scientists have long thought that coffee’s antioxidants were from caffeine or chlorogenic acid in green coffee beans. But coffee beans lose 90 percent of the chlorigenic acid during roasting, a finding that points to the Maillard reaction as the main source of antioxidants.
"Confirmation that the Maillard reaction is the principle contributor to the antioxidant capacity of coffee brews", Food Research International, February 02, 2011
A clinical trial conducted by Iranian scientists has found that drinking a yogurt beverage fortified with vitamin D (or vitamin D and calcium) improved management of blood sugar (glucose) levels in patients with type 2 diabetes. Management of blood sugar, called glycemic control, is critical in diabetes because elevated levels of glucose in the blood (hyperglycemia) over a long period can lead to harmful complications. In the study, 90 diabetics were randomly selected to consume plain yogurt with calcium but without vitamin D, or yogurt fortified with different levels of vitamin D and calcium twice a day for 12 weeks. Blood glucose levels were found to be lower in the groups that drank the vitamin D-fortified yogurt beverage, with or without added calcium.
"Daily consumption of vitamin D– or vitamin D + calcium–fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial", The American Journal of Clinical Nutrition, February 02, 2011
A month-long study of 21 healthy men and women found that tangerine tomatoes—an heirloom variety—may be better sources of lycopene than common red tomatoes. Lycopene is a powerful antioxidant that helps reduce or prevent damage to cells. In tomatoes, it occurs in two forms: trans-lycopene, contained in red tomatoes, and tetra-cis-lycopene, found in the tangerine variety. Study subjects alternated lycopene-free weeks with a week of either red or tangerine tomato-rich lunches. Scientists found that the tangerine tomato regimen resulted in higher levels of lycopene and lower oxidative damage, and suspect that the human body’s ability to more easily absorb tetra-cis-lycopene is the reason.
"Tangerine Tomatoes Top Reds in Preliminary Lycopene Study", News, Agricultural Research Magazine, USDA, February 01, 2011
A randomized two-year clinical trial involving 403 healthy postmenopausal women has found that a daily 80-120 mg supplement of soy hypocotyl isoflavones does not present a health risk, and may actually protect against cancer. The trial was designed to test the impact of soy isoflavone supplementation on osteoporosis, but researchers were also trying to determine if long-term supplementation led to adverse health outcomes. Only two women in the soy supplement groups experienced serious health problems: one case of breast cancer and one case of endometrial cancer. This “was less than the expected population rate for these cancers,” the researchers said. The supplement used in the study was the patented soy germ isoflavone product SoyLife from Frutarom.
"Clinical outcomes of a 2-year soy isoflavone supplementation in menopausal women", American Journal of Clinical Nutrition, February 01, 2011
A Danish study involving nine participants who ate diets containing the same amount of calories but varying levels of dairy fat and calcium over ten days found that a diet rich in dairy calcium reduced LDL (“bad cholesterol”) associated with high saturated dairy fat without affecting HDL cholesterol. The four diets consisted of low calcium and low fat, high calcium and low fat, low calcium and high fat or high calcium and high fat. Milk was the main high calcium source for participants. The low calcium diet included a protein drink containing amounts of whey, casein powders and lactose equivalent to milk. “Dairy calcium seems to partly counteract the raising effect of dairy fat on total and LDL-cholesterol, without reducing HDL-cholesterol,” the researchers concluded.
"Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet", British Journal of Nutrition, January 31, 2011
The pigment astaxanthin makes salmon pink, and may also help prevent dementia. Compounds called phospholipid hydroperoxides (PLOOH) occur in abnormal levels in the red blood cells (erythrocytes) of dementia sufferers. According to a Japanese study, astaxanthin seems to reduce PLOOH accumulation. After 12 weeks (a relatively short time), subjects who received daily supplements of astaxanthin showed significant reduction in PLOOH levels. Researchers found that when astaxanthin is absorbed into the body, it accumulates in red blood cells, at which point it displays antioxidant-like properties, preventing the buildup of PLOOH in those cells. Currently, the pigment’s main health benefits are to the eyes and skin, but it seems to improve joint and central nervous system health as well.
"Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes", British Journal of Nutrition, January 31, 2011
Australian scientists have uncovered evidence linking salt consumption, high blood pressure and risk of cardiovascular disease. Researchers showed that a high-salt meal affects the ability of blood vessels to widen within 30 minutes after being eaten. Though normal function returned after two hours, researchers are concerned about the potential long-term effects of a high-salt diet, as compromised blood vessel function is believed to lead to thickening of the arterial walls (atherosclerosis). Also, this response is similar to the body’s reaction to a meal high in saturated fats—known to contribute to increased risk of cardiovascular disease.
"Endothelial function is impaired after a high-salt meal in healthy subjects", American Journal of Clinical Nutrition, January 12, 2011
Strict vegetarians or vegans may face higher risk of having blood clots and atherosclerosis, or thickening and hardening of the artery walls, according to a review of research on the biochemistry of vegetarianism published in the past 30 years. While omnivores have significantly higher cardiovascular and obesity risks, strict vegetarianism is clearly not risk-free. Compared with omnivores, vegetarians have less vitamin B12 and n-3 polyunsaturated fatty acid in their "tissue membrane phospholipids," conditions that in turn can lead to higher heart attack and stroke risk. To counter this risk researchers suggest vegetarians/vegans supplement their diets with n-3 PUFA and vitamin B12.and lower plasma HDL-C. These conditions in turn can lead to heart attack and stroke.
"Chemistry behind Vegetarianism", Journal of Agricultural and Food Chemistry, January 04, 2011
Antioxidants found in pecans seem to reduce risk factors associated with cardiovascular disease, a U.S. study has found. In the study, 16 men and women aged 23 to 44 years ate a series of three diets: three ounces of whole pecans, three ounces of pecans blended with water, or a control meal without pecans but otherwise equivalent nutritionally. Researchers analyzed biomarkers in blood and urine, finding that the antioxidant gamma-tocopherol (vitamin E) in the body doubled eight hours after both pecan meals. After the whole pecan meal, oxidized LDL (or “bad”) cholesterol decreased 26 percent after eight hours. "This protective effect is important in helping to prevent development of various diseases such as cancer and heart disease,” the authors wrote.
"Pecans Acutely Increase Plasma Postprandial Antioxidant Capacity and Catechins and Decrease LDL Oxidation in Humans", The Journal of Nutrition, January 01, 2011
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Nutraceutical World, February 01, 2011
American Journal of Kidney Disease, February 01, 2011
Clinical Nutrition, February 01, 2011
University of Michigan Health System, January 31, 2011
The Observer, Guardian UK, January 30, 2011
Clinical Nutrition, January 18, 2011
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