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Omega-3 Supplement Did Not Ease Depression In Heart Patients Taking Sertraline

October 21, 2009: 05:48 AM EST
A placebo-controlled U.S. clinical trial found that enhancing sertraline antidepressant therapy with omega-3 fatty acid supplements did not improve depression in coronary heart disease patients after 10 weeks. The findings contradict earlier experimental results. In the study, published in the Journal of the American Medical Association, 122 heart disease patients suffering from severe depression received 50 mg of sertraline a day. Randomly selected patients also received 2 grams of omega-3 fatty acids a day, while the rest received corn oil capsules. The researchers found that depression symptoms in the placebo and omega-3 groups improved over time at comparable rates.
Robert M. Carney, Ph.D.; Kenneth E. Freedland, Ph.D., et al., "Omega-3 Augmentation of Sertraline in Treatment of Depression in Patients With Coronary Heart Disease", Journal of the American Medical Association, October 21, 2009, © American Medical Association
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