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A study by U.S. researchers has found that animal-derived saturated fatty acids such as palmitic acid are strongly linked to adverse health effects because they activate key regulatory molecules called Jun kinases that are implicated in the development of type 2 diabetes, insulin resistance, obesity and atherosclerosis. Unsaturated fatty acids, however, found in plants and cold water fish, not only do not activate those regulatory molecules, they actually block activation by palmitic acid. The researchers suggested that a better understanding of polyunsaturated fatty acids, such as EPA and related omega-3 fatty acids, could lead to the identification of EPA-like molecules – and creation of dietary supplements – that are more effective in reducing the risk of cardiovascular disease and diabetes.
"Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation", Cell, September 30, 2011
U.S. researchers have discovered that a steroid found in the mustard plant triggers a response in rats similar to anabolic steroids. Researchers fed healthy rats homobrassinolide, a type of brassinosteroid found in plants, orally each day for 24 days, then measured body weight, food consumption, and body composition. Rats receiving homobrassinolide experienced greater protein synthesis in muscle cells, gained more weight and slightly increased their food intake, without side effects. The researchers suggested that in the future it may be possible to breed or engineer plants such as the mustard for higher brassinosteroid content to produce functional foods that can treat or prevent diseases, decrease muscle wasting, and increase physical performance.
"Anabolic effect of plant brassinosteroid", FASEB Journal, September 29, 2011
Resveratrol, a health-promoting ingredient found in red grapes and red wine, stops breast cancer cells from growing by blocking the growth effects of estrogen, according to new U.S. and Italian research. The findings suggest for the first time that resveratrol counteracts the progression of a malignancy by inhibiting the proliferation of hormone-resistant breast cancer cells. The discovery is especially important for women with breast cancer whose tumors eventually become resistant to hormonal therapy. The researchers used several breast cancer cell lines expressing the estrogen receptor to test the effects of resveratrol. They treated the different cells with resveratrol, and left some cells untreated, finding a significant reduction in cell growth in cells treated by resveratrol. No changes were seen in untreated cells.
"Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38MAPK/CK2 signaling in human breast cancer cells", FASEB Journal, September 29, 2011
The popular herbal dietary supplement saw palmetto, which has long been marketed as a way to ease urinary symptoms associated with an enlarged prostate, is no more effective than a placebo, according to a clinical trial. An enlarged prostate can cause frequent urination and other problems. The probability of the condition increases with age; nine of ten men in their 70s and 80s are affected. The clinical trial was conducted at 11 North American clinical sites from June 2008 to October 2010 among 369 men aged 45 years or older whose peak urine flow was less than normal. Escalating doses of saw palmetto or placebo were given, starting at one, two, and then three pills of 320 milligrams per day. Doses were increased at 24 and 48 weeks. But saw palmetto had no more impact than the placebo in reducing urinary symptoms.
"Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial", Journal of the American Medical Association, September 28, 2011
Anti-caking compounds added to powdered products to protect vitamin C from moisture accomplish the opposite: they seem to speed up the nutrient’s degradation. Purdue University scientists studying the dissolving effect of humidity on crystalline solids – a reaction known as deliquescence – tested different anti-caking compounds mixed with sodium ascorbate, a common form of vitamin C that normally dissolves when humidity levels reach 86 percent. They found that the anti-caking agents caused the vitamin C to dissolve at lower humidity levels. When vitamin C dissolves, it loses its nutritional value. “No anti-caking agent improved the chemical stability of the vitamin, and most caused an increase in chemical degradation even if physical stability was improved,” the researchers wrote.
" Effects of Anticaking Agents and Relative Humidity on the Physical and Chemical Stability of Powdered Vitamin C", Journal of Food Science, September 28, 2011
A multi-year study of 121 older residents of Chicago has found that lower levels of vitamin B12 in the blood were associated with a shrinkage in brain volume and lower scores on cognitive tests. Vitamin B12 is found in animal-derived foods, including fish and meat, and especially liver, milk, eggs and poultry. Cognitive test scores ranged from -2.18 to 1.42, with an average of 0.23. The researchers found that for each increase of one micromole per liter of homocysteine – one of the markers of B12 deficiency – the cognitive scores dropped by 0.03 standardized units or points. They cautioned, however, that it is still too early to say that vitamin B12 supplementation could help prevent cognitive decline in older people.
"Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination", Neurology, September 27, 2011
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Natural Product Insider, September 22, 2011
British Journal of Nutrition, September 20, 2011
British Journal of Nutrition , September 19, 2011
Norwegian University of Science and Technology (NTNU) press release, September 19, 2011
International Journal of Food Science & Technology, September 15, 2011
Nutrition Journal, September 13, 2011
Reuters, September 08, 2011
Nutrition Journal, September 07, 2011
Journal of Physiology, September 01, 2011
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